Source GM Core pg. 88
Afflictions
Wherever there's life in the universe, there are also insidious perils that threaten the health and well-being of living creatures. Some of these afflictions, including many diseases, are inherent to the natural world. Others—curses and engineered diseases being the most notorious—exist solely to cause harm to others.
Afflictions strike creatures with potent and often escalating results. This section presents a variety of curses and diseases for use in your game.
Depending on the tone of the campaign, the GM might want to roll secret saving throws for PCs affected by an affliction. This is particularly effective when the affliction is an element within a survival or horror game, or when it's part of a mystery.
Curses
A curse is a manifestation of potent ill will. Curses typically have a single effect that takes place upon a failed saving throw and lasts a specified amount of time, or can be removed only by certain actions a character must perform or conditions they must meet. Rarely, curses will have stages; these follow the rules for afflictions.
Diseases
Exposure to disease can be a hazard, such as when PCs come into contact with a Stardust plague-ridden corpse. Such hazards grant XP as a simple hazard of the disease's level. When a disease gives a sickened condition that can't be reduced until it runs its course, that typically means the disease has symptoms such as difficulty swallowing, loss of appetite, or nausea that make eating and drinking difficult but not impossible. Despite the condition's prohibition on eating or drinking, a creature can slowly and carefully eat and drink as long as they aren't in an encounter.
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